Sub-Topics Wrinkles Also Try Aging News -02-05-07 Village Provides a Medical Mystery (ABC News) "In the foothills of the Italian Alps is a tiny village that may hold a clue to a medical mystery that has challenged researchers for centuries. Despite indulging in an artery-clogging diet that could make even an Italian grandmother cringe, the 400 or so residents of tiny Stoccareddo, Italy, have virtually no heart disease or diabetes, and often live into their 90s." 02-07 -04-07-09 Oldest Living Person Reaches 115 Years (LATimes.com) "Gertrude Baines, recorded as the oldest person in the world, celebrated her 115th birthday this morning, and well-wishers including President Obama and the Dodgers sent their regards." 04-09 -05-02-06 Study: Middle-Aged Americans Much Sicker Than British (ABC News) "Middle-aged, white Americans are much sicker than their counterparts in England, startling new research shows, despite U.S. health care spending per person that is more than double what Britain spends." 05-06 -06-08-09 Healthy Habits to Live to 100 (U.S. News) "The biggest factor that determines how well you age is not your genes but how well you live. Not convinced? A new study published in the British Medical Journal of 20,000 British folks shows that you can cut your risk of having a stroke in half by doing the following four things: being active for 30 minutes a day, eating five daily servings of fruit and vegetables, and avoiding cigarettes and excess alcohol." 06-09 -06-29-06 10 Myths About Our Bodies (ABC News) "And that busts another big brain myth — that you can't teach an old dog new tricks. Memory loss is not inevitable. Want to keep your brain young? Exercise it.'' " 'The data now indicate that an hour of games for 40 weeks can make your brain equivalent, your brain's real age, 10 years younger,' Roizen said." 06-06 -07-09-09 Longevity Quest Moves From the Lab to Life (MSNBC News) "Known as caloric restriction, or CR, the practice of reducing food intake by at least 30 percent and as much as 70 percent has been regarded for decades as the gold standard for boosting longevity." "The mTOR is a protein involved in the signaling responses of cells and its activity may account for the lifespan extension found in CR. “By tinkering with those pathways, it’s possible we can alter the cells’ aging processes,” Kennedy says." "Research on mTOR by Kennedy and Kaeberlein was recently boosted by the discovery of 25 shared genes that regulate aging in yeast and worms, organisms separated by 1.5 billion years of evolution. Equally remarkable, researchers found that 15 of those genes are present in humans." 07-09 -07-09-09 Low-Calorie Diet Slows Aging in Monkeys (MSNBC News) "So far, 37 percent of the monkeys who kept their regular diet have died of age-related diseases — compared with just 13 percent of the calorie-cut monkeys, a nearly three-fold difference, the researchers reported. A handful of other monkeys died of unrelated conditions, such as injury, not deemed affected by nutrition." "Death was not the only change. The calorie-cut monkeys had less than half the incidence of cancerous tumors or heart disease as the monkeys who ate normally. Brain scans showed less age-related shrinkage in the dieting monkeys. They also retained more muscle, something else that tends to waste with age." 07-09 -07-10-09 Dieting Monkeys Offer Hope for Longevity (New York Times) "A long-awaited study of aging in rhesus monkeys suggests, with some reservations, that people could in principle fend off the usual diseases of old age and considerably extend their life span by following a special diet." "Known as caloric restriction, the diet has all the normal healthy ingredients but contains 30 percent fewer calories than usual." 07-09 -07-26-07 Japanese Women and Icelandic Men Live Longest (MSNBC News) "Japanese girls born last year can expect to live to an average age of 85.8 years, making them the longest-lived in the world, according to figures released by the government on Thursday." "Their male compatriots fare less well, with a life expectancy of 79 years, second to Icelandic men at 79.4 years, the Health Ministry said." "Japan’s women have topped the world’s longevity ranks for 22 years, something researchers have attributed to their healthy diet and tight social ties, among other factors." 07-07 -09-12-06 Study: Where You Live Influences How Long You Live (MSNBC News) "Where you live, combined with race and income, plays a huge role in the nation's health disparities, differences so stark that a report issued Monday contends it's as if there are eight separate Americas instead of one." 09-06 -11-29-06 Fruit and Vegetables May Protect From Memory Losses (MSNBC News) "Purple fruits and vegetables, such as blueberries, cranberries and Concord grapes, may be especially beneficial for the brain, says Joseph. In a study on aging mice genetically engineered to develop Alzheimer's, Joseph was able to improve their cognitive function by feeding the animals a diet high in blueberries." 11-06 Fifteen Ways to Live Longer (Forbes.com) "Where you live, combined with race and income, plays a huge role in the nation's health disparities, differences so stark that a report issued Monday contends it's as if there are eight separate Americas instead of one." 11-06 How to Stay Fit for Life (US News) "Baby boomers may be getting older, but many are still avid, if not obsessive, exercisers. And they want to stay that way. " 06-07 Papers -02-01-07 The Social Burden of Longer Lives (LiveScience.com) "Now, after countless false starts and disappointments, some scientists say we could finally be close to achieving lifetimes that are, if not endless, at least several decades longer. This modern miracle, they say, will come not from drinking revitalizing waters or from transmuted substances, but from a scientific understanding of how aging affects our bodies at the cellular and molecular levels." 01-07 -07-03-07 Beauty After 40 (CNN News) "You'll get spots on your hands and bunions on your feet. Your nose and ears may appear to have grown out of proportion to your face. And that expression "long in the tooth" will endearingly apply to you: A receding gum line will make your teeth look bigger." "I can't believe you're still reading this. Okay, as long as you're staying, I'll tell you how you can look beautiful as you age." 07-07 113-Year-Old Woman Could Hold Key to Long Life (WMUR.com) "Many have wondered whether there is a fountain of youth or some way to live forever. Now, scientists are looking at a New Hampshire woman who may hold the key to that question." 06-08 15 Ways to Live Longer (Forbes.com) Lists lifestyle ingredients that have correlated with longer life. 08-07 A Longevity Gene (ABC News) "Living for 100 years is an unlikely prospect for most of us. But for those lucky few who make it to the century mark, a crucial gene variation relating to cholesterol levels may play an important part in their longevity." 12-06 Aging (Wikipedia.org) "Ageing or aging is the process of systems' deterioration with time. This article focuses on the social, cognitive, cultural, and economic effects of ageing." "Drug companies are currently searching for ways to mimic the lifespan-extending affects of caloric restriction without having to severely reduce food consumption, and with respect to cellular senescence, it has been shown that individual cells can be immortalized by the introduction of an additional gene for telomerase." 04-07 Aging Better (U.S. News) "Baby boomers would like to believe that terms like 'over the hill' will never apply to them. And they could, in fact, be right. While there's no stopping time, there's plenty you can do to foil the aging process. "We now have a much greater understanding of aging mechanisms," says Dean Ornish, professor of medicine at the University of California-San Francisco, "to the extent that we know which changes help you live longer but, more important, age better.' " 01-09 Anti-Aging Therapies Now Promising (ScienceDaily.com) "The day when people retire at 85 and live well into their 100s may be on the horizon, thanks to promising research in anti-aging therapies, researchers said Friday." 02-06 Five Environmental Health Factors for Longevity (MSNBC News) "Here are five environmental health factors that can affect both the length and quality of your life-and what you can do to counteract them." 11-06 Five Things that Will Age You (ABC News) "People have searched for the fountain of youth for centuries. And, while it remains elusive, there are things you can do to slow the aging process, or speed it up. Oprah's favorite doc, Dr. Mehmet Oz, discusses the five things that age people most." 02-09 For Longevity, Other Factors Pale in Comparison to "Education" (New York Times) "The one social factor that researchers agree is consistently linked to longer lives in every country where it has been studied is education. It is more important than race; it obliterates any effects of income." "And, health economists say, those factors that are popularly believed to be crucial — money and health insurance, for example, pale in comparison." 01-07 Genes Control Aging (EurekAlert.org) "Two University of Colorado at Boulder researchers working with GenoPlex Inc. in Denver have identified a biological switch that controls lifespan in tiny worms, a finding that could have applications for mammals, including people." Discusses DAF-2 and DAF-16. College Level. 9-02 Girl Doesn't Age (ABC News) "Brooke Greenberg is the size of an infant, with the mental capacity of a toddler." "She turned 16 in January." "Walker, of the University of South Florida, believes that if the gene can be isolated, it may provide clues to questions about why we age and die." 06-09 HGH for Longevity (MayoClinic.com) "If you're willing to pay thousands, some doctors promise to reverse the signs of aging with human growth hormone (HGH). Before you sign up, get the facts." 04-07 Intellegent Decisions Linked to Longevity (MSNBC News) "So while it's true that having a high IQ makes you more likely to have wealth and a higher-social-status job, it's making smart and healthy decisions--and not simply the status and savings--that help a person live longer." 02-06 Is Aging a Disease? (SageCrossroads.com - Moody and Caplan) Caplan: "So just to recap: Aging looks like disease. And the only reason we don’t call it a disease is that we think of it as universal and natural. But it isn’t always universal, because it happens to different people at different rates. And, I don’t think it’s natural. I think it’s unnatural. It’s something that just got designed into us." 2-4. Living to 100 Years (US News) "People who've had long lives presumably hold keys to good health, and the rest of us might do well to learn from them. That's why Thomas Perls, a geriatrician at the Boston University Medical School, studies centenarians—people who've been kicking for a century or more. As head of the New England Centenarian Study, the world's largest study of such people, Perls has researched the habits, genes, and medical histories of about 900 centenarians. Perls thinks centenarians offer an unparalleled look into how we can all age gracefully, healthfully, and happily." 07-07 Longevity - Aubrey de Grey's View (AntiAgeingConference.com) "The central goal of his biogerontology work is to expedite the development of a true cure for human aging. In his view, the main obstacle to developing such technology is the position of biogerontology at the boundary between basic science and medicine: the fundamental knowledge necessary to develop truly effective anti-aging medicine mostly exists, but the goal-directed frame of mind that is best suited to turning research findings into tools is very different from the curiosity-driven ethos that generated those findings in the first place. As a scientist with a training in an engineering discipline (computer science), he is unusually well placed to bridge this gap. He attempt to do so in three main ways: basic biogerontology research, identify and promote specific technological approaches to the reversal (not merely the prevention) of various aspects of aging, and argue in a wide range of fora (extending well beyond biologists) for the adoption of a more proactive approach to extending the healthy human lifespan sooner rather than later. Provides an article related to preventing aging and improving longevity." 2-5 Longevity - Aubrey de Grey's View (Methuselah Foundation) "Dr. Aubrey de Grey, Chairman of The Methuselah Foundation (www.Mprize.org), awarded the first ever Methuselah Mouse Rejuvenation Prize to Dr. Stephen Spindler, who lead the first experiment to achieve rejuvenation in middle-aged mice, making them biologically younger while extending their lifespans." 2-5 Longevity - Aubrey de Grey's View (Technology Review) "De Grey has mapped out his proposed course in such detail that he believes it may be possible for his objective to be achieved within as short a period as 25 years, in time for many readers of Technology Review to avail themselves of its formulations—and, not incidentally, in time for his 41-year-old self as well." 2-5 Longevity - Kurzweil's View (CBS News) Provides an article related to preventing aging and improving longevity. 2-4. Longevity - Research on Extending Life (CBC) Provides results on efforts to reduce human aging through genetic research. 3-00 Longevity - Three Theories (Nature - Gee) Suggests three basic processes for aging. 10-00. Longevity News (SageCrossroads.com) Provides news and articles related to preventing aging and improving longevity. 2-4. Longevity for U.S. Presidents (U.S. News) "When a new President takes the oath of office, he often exudes a youthful optimism. But Presidents tend to leave Washington visibly wearing the stress of their position. According to a theory advanced by Michael Roizen, chair of the Wellness Institute at the Cleveland Clinic and co-founder of RealAge.com, presidents age approximately two years for each calendar year in office." 02-09 Man Lives Until 112 on Bad Diet (MSNBC News) "George Johnson, considered California’s oldest living person at 112 and the state’s last surviving World War I veteran, had experts shaking their heads over his junk food diet." 09-06 Men Have a Biological Clock Too (U.S. News) "Older males face higher risk of fathering children with medical problems, research finds." 02-09 New Pill May Slow Aging (ABC News) "Dr. Joe McCord's latest research may unravel the mystery of aging. And if he succeeds, the answer could come in the form of a little yellow pill called Protandim." 6-5 Older People Don't See Themselves as "Old" (USA Today) "If you've been telling yourself you're not old yet, you fit right in." "No matter what their chronological age, most people say that they aren't yet 'old' — and that they feel younger than their birthday count, according to a new nationally representative survey of almost 3,000 adults by the Pew Research Center." 06-09 Oldest Person Currently - Maria Capovilla (Bloomberg.com) "A 116-year-old Ecuadorian woman took over the mantle of the world's oldest person after documents proved she is older than a 115-year-old American who held the title, Guinness World Records said." 03-06 Oldest Person Currently - Maria Capovilla (Wikipedia.org) "Maria Esther de Capovilla of Guayaquil, Ecuador (born September 14, 1889) was named the "World's Oldest Person" by Guinness World Records, Dec 9, 2005." 03-06 Oldest Person Recorded in Modern History (Wikipedia.org) "Jeanne Louise Calment (February 21, 1875 – August 4, 1997) has the longest confirmed lifespan (122 years and 164 days) for any human being in history. Her lifespan has been thoroughly documented by scientific study; more records have been produced to verify her age than for any other case." 03-06 Perricone: Prescription for Aging Beautifully (Oprah.com) "Inflammation is at the basis of age-related diseases such as heart disease, diabetes, cancer, auto immune disease, and wrinkled, sagging skin. The wrong foods—such as sugar, processed foods, pasta, breads, pastry and baked goods—can increase levels of the pro-inflammatory peptides." "Sugar is the number one enemy. It causes inflammation that destroys our bodies and attaches to collagen, which results in stiff, inflexible, sagging skin. Controlling our blood sugar level and insulin levels will improve our health and give us beautiful, youthful skin." "The anti-inflammatory diet consists of high quality protein, like that found in fish, colorful fresh fruits and vegetables, and adequate amounts of good fat, like that found in salmon, flax, nuts, seeds and olive oil." 12-05 Prevention Activities for Better Aging (CooperAerobics.com) Provides over a dozen articles to help prevent problems with health and aging. 2-04 Resveratrol (Wikipedia.org) "Resveratrol is a phytoalexin produced by several plants that is sold as a nutritional supplement. A number of beneficial health effects, such as anti-cancer, antiviral, neuroprotective, anti-aging, anti-inflammatory and life-prolonging effects have been reported in non-human species.(i.e. rats)." Common misspellings of Resveratrol include Reseveratol, Resveratol, Resveratral and Resverratrol. 12-06 Resveratrol and Health (BayBlab) "That's where Sirtris comes in. They develop compounds that are analogs of resveratrol to improve potency and bioavailability (and patentability), and test those compounds. And Big Pharma (GSK) has taken notice, decided this is viable science, and acquired Sirtris in the hopes of turning these compounds into diabetes, anti-obesity or anti-aging drugs. Like other examples we've discussed this is a case of a natural or alternative medicine becoming mainstream (or, rather, the beginning steps of that process)." "The moral of the story isn't that natural products work. In this case it doesn't - all resveratrol supplements will give you is expensive urine. The point is that if the science is there, the medicine will come." 01-09 Resveratrol and Health (Bloomberg.com) "SRT501 mimics resveratrol, which has been linked to longevity, Sirtris scientists said. The Sirtris molecule is 1,000 times more potent than resveratrol, and could lead to solutions for diseases of aging including cancer and diabetes, according to an article published in the journal Nature." 01-09 Resveratrol and Health (SirtrisPharma.com) Sirtris Pharmaceuticals: Resveratrol reduces fat and boosts endurance by activation of SIRT1, first aging gene shown to accelerate human metabolism. 01-09 Resveratrol and Health (Wikipedia.org) "Resveratrol is a phytoalexin produced naturally by several plants when under attack by pathogens such as bacteria or fungi. Resveratrol has also been produced by chemical synthesis[1] and is sold as a nutritional supplement derived primarily from Japanese knotweed." 01-09 Twins and Aging: How Not to Look Old (Time.com) "A forthcoming study in the journal Plastic and Reconstructive Surgery offers one surprising idea: as you age, don't be afraid to put on a few pounds. Fat, it turns out, can significantly smooth out wrinkles and give you a younger-looking face." 02-09 Vitamin D Lowers Risk of Death (Time.com) "Doctors have long known that vitamin D is essential to good health. Get enough of it and it ensures strong bones and teeth. But a new study this week suggests an even more extraordinary benefit: a lower risk of death." 09-07 Want to Make It to 85? (MSNBC News) "One of the largest, longest studies of aging found one more reason to stay trim and active: It could greatly raise your odds of living to at least age 85." 11-06 World's Oldest Man Dies (Time.com) "The world's oldest man, 113-year-old World War I veteran Henry Allingham, died Saturday after spending his final years reminding Britain about the 9 million soldiers killed during the conflict." 07-09 World's Oldest Man Dies (Time.com) "Tomoji Tanabe, the world's oldest man, died in his sleep at his home in southern Japan on Friday, a city official said. He was 113." 06-09 World's Oldest People (Wikipedia.org) "The following tables list only the verified oldest people in world in ordinal rank, such as oldest person or oldest man. A supercentenarian is considered verified if their claim has been accepted by an international body that specifically deals in longevity research, such as the Gerontology Research Group or the Guinness Book of World Records. The longest unambiguously documented lifespan is that of Jeanne Calment of France (1875–1997), who died at age 122 years and 164 days. She met Vincent van Gogh at age 14.[1]" 07-09 Projects Longevity (Northwestern Mutual) Provides life expectancy, based on factors that you provide. 1-04 Longevity (Northwestern Mutual) Provides life expectancy, based on factors that you provide. 10-09 What Is Your "Real Age"? (RealAge.com) Assesses your biological aging related to lifestyle choices, in contrast to your calendar age. 01-07 World's Oldest Man Dies at 113 (USA Today) "Fred Hale Sr., documented as the world's oldest man, died Friday. He was 113 years old. Hale died in his sleep Friday at The Nottingham in suburban Syracuse, while trying to recover from a bout of pneumonia, said his grandson, Fred Hale III. He was 12 days shy of his 114th birthday." 11-04 Purchase Resources New Pill May Slow Aging (ABC News) "Thirteen normal, healthy human subjects ranging in age from 20 to 78 received the final commercial formulation of Protandim, now containing five components (one capsule, 675 mg daily, for 30 days). Blood was drawn for analysis at day 0 and again at day 30. Some of the subjects took no other antioxidant supplements, while some took supplements of vitamin C and/or vitamin E and/or multivitamins." "After 30 days of Protandim supplementation plasma TBARS declined significantly, more so in the older subjects (about 69%) than in the younger subjects (about 30%). The age-dependent increase seen prior to supplementation was no longer present. The average TBARS concentration decreased to 0.95 micromolar, a level one would expect to see in a 15 year old." Awesome Library does not endorse this product but provides it as an example. 6-5

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