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News -03-20-07 Malaria-Resistant Mosquito Developed (CBS News) "Researchers have developed a malaria-resistant mosquito, a step that might one day help block the spread of an illness that has claimed millions of lives around the world." 03-07 -12-11-05 Anti-Malaria Vaccine Discovered (Scientific American) "A new vaccine stimulated human immune cells to recognize and kill malaria parasites in a recent clinical trial. The vaccine proved effective in both infected human blood samples and mice whose immune systems had been modified to mimic that of humans." 12-05 -12-11-05 Fever May Be Bad for Patients With Malaria (Scientific American) "Using samples obtained from 12 patients suffering from acute malaria infections, the team found that the stickiness of the parasitized blood cells increased upon heating." "The results offer new insight into why malaria patients often deteriorate significantly at the fever stage. They also suggest that, contrary to one popular school of thought, which holds that quelling the fever slows the body's ability to clear the parasite, fever reduction may in fact stymie disease progression and enhance antimalarial drugs' ability to block parasite development." 12-05 -12-11-05 Freeing Merozoites a Key in Spread of Malaria (Scientific American) "An estimated 300 to 500 million people suffer from malaria, making it one of the most devastating diseases known." "While inside a red blood cell, the malaria parasite produces so-called "merozoites," which go on to infect other cells. Suspecting that protein-degrading enzymes, o r proteases, might play a role in rupturing the blood cells and freeing the merozoites, researchers from Washington University studied the effects of a protease-blocking drug dubbed E64 on merozoite escape. Although the red blood cell membrane gave way, the drug appeared to thwart the rupture of a second membrane, which encases clusters of merozoites." 12-05 -12-11-05 Malaria a Fairly New Disease (Scientific American) "Malaria may not be an ancient plague but rather a fairly young one—about 10,000 years young. According to a study published Friday in Science, the initial spread of the disease parallels that of agriculture and early human civilization. So by looking at mutations in our own genes, scientists can track malaria's origins." 12-05 Papers Malaria Research Funded (CBS News) "Malaria research accounts for about one-third of 1 percent of the total amount of money spent on medical research and development, even though it accounts for 3 percent of all the productive years of life lost to diseases, a new report has found." 10-05 Small Children Die from Poverty (WashTimes.com) "The World Health Organization (WHO) says nearly 11 million children under age 5 die each year from easily preventable and cheaply cured diseases — including pneumonia, diarrhea, malaria and complications during the first year of life." "It costs just 2 cents for a six-month supply of vitamin A supplement, 15 cents for a five-day course of antibiotics to treat pneumonia and $15 to immunize a child against the six main childhood diseases, according to the U.S. Coalition for Child Survival."  "A bed net, treated to kill and repel malarial mosquitoes, costs less than $10." "The United States spent $1.7 billion on global health, education and population programs in 2001, according to rough calculations based on figures from the Organization for Economic Cooperation and Development. France was the second-biggest spender, with $1.1 billion in aid, followed by Germany at $1 billion and Japan at nearly $800 million." 9-03

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