News -04-27-06 New Method to Prevent AIDS Under Study (New York Times) "The most striking studies suggest that men can lower their own risk of infection by roughly two-thirds, and that infected men can reduce the odds of transmitting the virus to their partners by about 30 percent, simply by undergoing circumcision. Research suggests that the cells on the underside of the foreskin are prime targets for the virus and that tears and abrasions in the foreskin can invite the infection." "But World Health Organization experts say it would be premature to recommend circumcision until results come in from two randomized controlled trials involving nearly 8,000 people in Kenya and Uganda. Preliminary results could be released by late June." 04-06 Papers Circumcision Pros and Cons (U.S. News) "Well, a study of 5,000 initially uncircumcised Ugandan men in this week's New England Journal of Medicine found that once the men underwent circumcision, their rate acquiring herpes virus infection plunged by 28 percent and they were 35 percent less likely to get infected with human papillomavirus (HPV), which is responsible for genital warts and, in women, cervical cancer." "Previous research has shown that circumcision reduces infection with the HIV virus by 60 percent—although other studies have shown no difference in rates of certain sexually transmitted diseases between circumcised and uncircumcised men." 04-09 Stein Contemplates Circumcision for His Son (Time.com) "So in a few weeks, I'm going to buy some bagels, call a mohel who is also a pediatric surgeon and believes in local anesthetic, and do something that I'm pretty sure is wrong." 03-08 Study: Circumcision Helps Prevent 2 STDs (Time.com) "Circumcision not only protects against HIV in heterosexual men, but it also helps prevent two other sexually transmitted infections, a large new study found. Circumcised males reduced their risk of infection with HPV, or human papillomavirus, by 35 percent and herpes by 28 percent. However, researchers found circumcision had no effect on the transmission of syphilis." "Landmark studies from three African countries including Uganda previously found circumcision lowered men's chance of catching the AIDS virus by up to 60 percent." 03-08 Study: Circumcision in Males Associated with Fewer AIDS Infections (BBC News) "They calculated that within a decade some two million new HIV infections and 300,000 deaths could be prevented. And in the ten years after that, a further 3.7 million infections and 2.7 million deaths could be avoided - with one in four of the deaths prevented being in South Africa." 07-06

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