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CRISPR

Papers
  1. Halting Production of Brain-Destroying Proteins (News.ScienceMag.org)
      "Huntingtons disease, a neurological condition caused by brain-destroying mutant proteins, starts with mood swings and twitching and ends in dementia and death. The condition, which afflicts about 30,000 Americans, has no cure. But now, a new gene-editing method that many believe will lead to a Nobel Prize has been shown to effectively halt production of the defective proteins in mice, leading to hope that a potent therapy for Huntingtons is on the distant horizon."

      "That new method is CRISPR, which uses RNA-guided enzymes to snip out or add segments of DNA to a cell." 11-15

  2. Using CRISPR to Alter Human Gene Defects (ScienceMag.org)
      "CRISPR opens the door to an unprecedented level of control over the human genome. Older techniques for editing DNA have been blunt and unreliable at best; CRISPR, on the other hand, is quickly emerging as the precision blade to those butter-knife approaches."

      "CRISPR allows scientists to precisely snip out and replace genes, and for the first time, the newly green-lit experiment will apply this to the so-called germline cells in an embryo—the DNA in an embryo so early in its development that all of its resulting cells will carry the change—and pass it on to the next generation. Monday’s decision has been eagerly anticipated by scientists around the world." 02-16

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