Terms: multiple sclerosis
Matches: 14    Displayed: 7

Categories

• Reference and Periodicals > Medical > Diseases and Conditions > Multiple Sclerosis

Specific Results

1. -09-25-06 Study: Multiple Sclerosis Drug Successful (Bloomberg.com)
   "Shares of Acorda Therapeutics Inc. rose almost fourfold after the company said its experimental Fampridine drug helped people with multiple sclerosis walk faster." 09-25-06

2. Multiple Sclerosis - Fact Sheet (Family Caregiver Alliance)
   "Multiple Sclerosis (MS) is one of the most commonly occurring chronic neurological diseases. MS affects the central nervous system (CNS)—the brain and spinal cord—and is thought to be caused by a disorder of the immune system, or auto-immune disorder. About 400,000 people nationwide, and possibly 2.5 million people worldwide, have MS. The disorder affects people of all ages, but onset is most likely to occur between the ages of 20 and 40. Women are twice as likely as men to develop MS." 1-04

3. Beta Glucans (WebMD.com)
   "Beta glucans are used for high cholesterol, diabetes, cancer, and HIV/AIDS. Beta glucans are also used to boost the immune system in people whose body defenses have been weakened by conditions such chronic fatigue syndrome, or physical and emotional stress; or by treatments such as radiation or chemotherapy. Beta glucans are also used for colds (common cold), flu (influenza), H1N1 (swine) flu, allergies, hepatitis, Lyme disease, asthma, ear infections, aging, ulcerative colitis and Crohn's disease, fibromyalgia, rheumatoid arthritis, and multiple sclerosis."
   
   "People apply beta glucans to the skin for dermatitis, eczema, wrinkles, bedsores, wounds, burns, diabetic ulcers, and radiation burns." 07-10

4. Vitamin D: You May Have a Serious Vitamin D Deficiency (New York Times)
   "Studies indicate that the effects of a vitamin D deficiency include an elevated risk of developing (and dying from) cancers of the colon, breast and prostate; high blood pressure and cardiovascular disease; osteoarthritis; and immune-system abnormalities that can result in infections and autoimmune disorders like multiple sclerosis, Type 1 diabetes and rheumatoid arthritis."
   
   "Most people in the modern world have lifestyles that prevent them from acquiring the levels of vitamin D that evolution intended us to have." 07-10

5. -01 Breakthrough in Understanding Disease (New York Times)
   "The findings, which are the fruit of an immense federal project involving 440 scientists from 32 laboratories around the world, will have immediate applications for understanding how alterations in the non-gene parts of DNA contribute to human diseases, which may in turn lead to new drugs. They can also help explain how the environment can affect disease risk. In the case of identical twins, small changes in environmental exposure can slightly alter gene switches, with the result that one twin gets a disease and the other does not."
   
   "As scientists delved into the 'junk' — parts of the DNA that are not actual genes containing instructions for proteins — they discovered a complex system that controls genes. At least 80 percent of this DNA is active and needed. The result of the work is an annotated road map of much of this DNA, noting what it is doing and how. It includes the system of switches that, acting like dimmer switches for lights, control which genes are used in a cell and when they are used, and determine, for instance, whether a cell becomes a liver cell or a neuron."
   
   "In one of the Nature papers, researchers link the gene switches to a range of human diseases — multiple sclerosis, lupus, rheumatoid arthritis, Crohn’s disease, celiac disease — and even to traits like height. In large studies over the past decade, scientists found that minor changes in human DNA sequences increase the risk that a person will get those diseases. But those changes were in the junk, now often referred to as the dark matter — they were not changes in genes — and their significance was not clear. The new analysis reveals that a great many of those changes alter gene switches and are highly significant."
   
   " 'Most of the changes that affect disease don’t lie in the genes themselves; they lie in the switches,' said Michael Snyder, a Stanford University researcher for the project, called Encode, for Encyclopedia of DNA Elements." 09-12

6. Autoimmune Condition Locks Up Woman (ABC News)
   "Tunick was experiencing the first of many episodes in which her muscles seized up painfully, a rare neurological condition known as Stiff Person Syndrome (SPS). Though the cause is unknown, SPS has features of an autoimmune disease in which the body's immune system attacks itself, setting off, in this case, muscle spasms."
   
   "And because the syndrome is so rare, it is often mistaken for a variety of musculoskeletal conditions, including Parkinson's disease, multiple sclerosis, fibromyalgia or something of a psychosomatic nature." 10-09

7. Gut Microbiome Alterations in Alzheimer's Disease (Alzheimer Research Forum)
   Alterations in the composition of this complex ecosystem have been associated with the development of a variety of gastrointestinal and metabolic diseases including inflammatory bowel disease (IBD), obesity, diabetes, and insulin resistance10. More recently, the influence of gut microbiota on central nervous system function – often referred to as the gut-brain axis – has received significant attention, and alterations in the gut microbiome have been associated with neurological conditions including autism spectrum disorder, multiple sclerosis, and Parkinson’s disease11–13."
   
   With respect to dementia, a recent study in cognitively impaired elderly participants investigated a limited number of pro- and anti-inflammatory gut bacterial taxa and found altered abundance in individuals with positive amyloid positron emission tomography (PET) imaging14. In addition, recent studies in transgenic mouse models of AD have demonstrated that manipulating gut microbiota can influence cerebral amyloid deposition15,16. However, to date there have been no comprehensive surveys of whole gut microbiota in humans with AD. In this study, we performed bacterial 16S ribosomal RNA (rRNA) gene sequencing of DNA isolated from fecal samples in order to characterize the gut microbial communities in individuals with and without a clinical diagnosis of dementia due to AD. In addition, we examined the relationship between gut microbiota and AD pathology as measured by cerebrospinal fluid (CSF) biomarkers of AD." 06-24-2019