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News -01-11-06 Obesity Drug Based on Genetic Research (ABC News) "In the coming year, the French pharmaceutical giant Sanofi-Aventis plans to release what many believe could be one of the first truly effective anti-obesity drugs. Preliminary data from large trials have suggested that weight loss is much greater than with any current drugs on the market." "The drug, rimonabant, targets receptors of cannabinoid 1, which stimulates appetite and other cravings (including nicotine) in the brain. By blocking cannabinoid 1's receptors, rimonabant helps people beat their cravings and lose weight." 01-06 -03-04-06 Hoodia May Suppress Hunger (CBS News) Hoodia is "very different from diet stimulants like Ephedra and Phenfen that are now banned because of dangerous side effects. Hoodia doesn't stimulate at all. Scientists say it fools the brain by making you think you’re full, even if you've eaten just a morsel." 03-06 -06-14-07 First Approved Diet Drug (CBS News) "The first over-the-counter weight-loss pill approved by the FDA, Alli works by blocking about one-fourth of consumed fat. The drug's makers don't claim that it's a miracle drug — a reduced-calorie, low-fat diet and regular exercise are necessary companions for it to be effective — but dieters are eager to reap its potential rewards." "Alli users must contend with some less-than-glamorous side effects — gas, oily discharge and an inability to control bowel movements — and skeptics of the pill's enduring benefits point out that those aren't the only reasons to think twice before taking the drug." 06-07 -11-27-04 African Plant May Reduce Appetite (CBS News) "Each year, people spend more than $40 billion on products designed to help them slim down. None of them seem to be working very well." "Now along comes hoodia. Never heard of it? Soon it'll be tripping off your tongue, because hoodia is a natural substance that literally takes your appetite away." 11-04 Papers Leptin Helps Regulates Body Weight (Colorado State University) "Leptin (from the Greek leptos, meaning thin) is a protein hormone with important effects in regulating body weight, metabolism and reproductive function." Editor's Note: Leptin levels seem to be affected by sleep. Insufficient sleep seems to increase leptin levels. 9-05 Obesity - Diet Drug Trial Shows Patients Keep Weight Off (applesforhealth) A clinical trial in Europe of the weight-loss drug Meridia shows obese patients were able to maintain their initial weight loss for a two-year period. 06-11-99. Obesity - Fat Blocking Pill Aids In Weight Loss (applesforhealth) Scientists are claiming a victory in the battle of the bulge with a pill that blocks a third of the fat a person eats from making the trip from lips to hips. 06-04-99. Obesity - Getting Control Of The "Fat" Hormone (applesforhealth) Leptin, the so called "fat" hormone apparently has a low tolerance for exercise. A study presented at an annual conference on cardiovascular disease indicates lean, physically active people have low leptin levels. 03-10-00. Obesity Busters Aim At New Target (applesforhealth) Scientists looking for weapons against obesity may have found a new target. Researchers at the Whitehead Institute for Biomedical Research in Cambridge, Mass., and Millennium Pharmaceuticals, Inc., have identified a protein in the small intestine that plays a key role in the body's uptake of dietary fat. 10-08-99. Obesity Drug Leptin Shows Promise (applesforhealth) In the first published study of the hormone leptin for typical cases of obesity in humans, scientists have shown that the genetically engineered drug does help people knock off pounds of fat. 11-05-99. Two Substances Which Tell the Body to Stop Eating (BBC News) "Scientists have identified two substances which tell the body to stop eating - and say they could be used to create drugs [to] treat obesity." "Boosting levels of the PYY3-36 hormone was found to reduce appetite and calorie consumption in both lean and overweight people." 03-07

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