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News -02-06-06 Study: Up to 79% of Late-Onset Alzheimer's is Genetic (USA Today) "Genes account for 58% to 79% of a person's risk of developing late-onset Alzheimer's, a study reports today. It's the largest genetic study of Alzheimer's ever." 02-06 -03-14-06 Protein Complex in Brain Found to Cause Memory Loss (ABC News) "Scientists have identified a substance in the brains of mice that causes memory loss, which could be a target for drugs to treat patients with Alzheimer's disease." " 'Finding the specific cause of memory loss and cognitive decline gives scientists a protein complex to target,' said Professor Karen Ashe of the University of Minnesota Medical School in Minneapolis, who headed the research team." 03-06 -06-23-08 New Clue to the Cause of Alzheimer's Disease (Time.com) "Now, researchers have caused Alzheimer's symptoms in rats by injecting them with one particular form of beta-amyloid. Injections with other forms of beta-amyloid did not cause illness, which may explain why some people have beta-amyloid plaque in their brains but do not show disease symptoms." 06-08 -06-26-06 New Test for Alzheimer's Disease (CBS News) "A new test may help scientists answer a perplexing 'which came first' question about the development of Alzheimer's disease, possibly pointing the way to earlier diagnosis or even treatment." " 'The paper describes an extremely interesting and potentially important advance,' said Dr. Samuel Gandy of Thomas Jefferson University in Philadelphia said. 'This method is light-years ahead of any existing technology for approaching the issue,' said Gandy, who was not part of the research team." 06-06 -12-08-05 Protein p25 Associated with Alzheimer's Disease -- and Creativity (HHMI.org) " Researchers have found evidence that may partially exonerate a protein known to be a culprit in the progression of Alzheimer's disease. Their new studies show that the protein p25, which wreaks havoc in the brains of patients with Alzheimer's disease, also has a good side in promoting the plasticity of the brain." 12-05. 11-12-04 New Compound May Slow Alzheimer's Disease (Scientific American) "Now, borrowing a trick from soil bacteria, researchers have designed a small molecule that effectively forms a new drug on the spot by teaming up with a large protein that is common inside cells. As reported today in Science, the resulting complex binds to fragments of beta-amyloid protein and keeps them from sticking together to form the 'plaques' that are a hallmark of Alzheimer's disease." 8-04 Papers Alzheimer's Disease - Research on Alzheimer's Disease and Diet (Fisher) Provides recommendations to combat Alzheimer's Disease through diet. Research Alzheimer's Disease - Memory Loss in Mice Reversed (Scientific American) More than four million Americans currently suffer from Alzheimer's disease and the number is expected to balloon as the population ages. The results of a new mouse study offer fresh hope that the damage inflicted by the disease could be at least partially reversible." "In humans, two different substances that accumulate in the brain are implicated in Alzheimer's: twisted neurofibrillary tangles, which include tau proteins, and amyloid deposits comprised of toxic plaque build-up. For the study mice, after the mutant tau gene was dampened and some memory regained, their neuron numbers stabilized but the tangles remained. The tangles themselves may therefore not be responsible for causing memory problems, at least in mice." 7-05 Alzheimer's Disease Research (Alzheimer Research Forum) Provides news on Alzheimer's Disease. 7-04 Alzheimer's Disease Research (National Center for Biotechnology Information) Provides a summary of gene research related to preventing Alzhimer's disease. "Recently, use of a mouse model of the disease identified an enzyme that may be responsible for the increase in amyloid production characteristic of AD. If a way to regulate this enzyme could be found, then AD may be slowed or halted in some people." 2-02 Alzheimer's Research May Delay Effects (CBSNews.com) Summarizes research on a human to see if injection of a genetically engineered nerve growth factor will delay the effects of Alzheimer's Disease. 2-01 Cure for Early Alzheimer's in Mice (Scientific American) "Alzheimer's disease is characterized by two separate brain lesions: plaques and tangles. The results of a new mouse study indicate that an experimental immune therapy that targets the former can also impact the latter, so long as the disease has not progressed to an advanced state." 8-04

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